Transforming growth factor-beta-related signaling in blastocyst morphogenesis
نویسندگان
چکیده
منابع مشابه
Transforming growth factor-beta-related signaling in blastocyst morphogenesis
permissive to ES cell derivation compared to others. Second, when generating host/ES cell chimeras, certainmouse strain combinations are significantlymore successful than others.Wepropose that differences in the responsiveness to certain developmental cues may influence the timing or manner of lineage specification, thus causing inter-strain variance. To test this, we studymouse strains (129 Sv...
متن کاملCrosstalk between vascular endothelial growth factor, notch, and transforming growth factor-beta in vascular morphogenesis.
Vascular morphogenesis encompasses a temporally regulated set of morphological changes that endothelial cells undergo to generate a network of interconnected tubules. Such a complex process inevitably involves multiple cell signaling pathways that must be tightly coordinated in time and space. The formation of a new capillary involves endothelial cell activation, migration, alignment, prolifera...
متن کاملTransforming growth factor-beta signaling in stem cells and cancer.
Transforming growth factor-beta (TGF-beta) and TGF-beta-related proteins, such as the bone morphogenetic proteins, have emerged as key regulators of stem cell renewal and differentiation. These proteins have disparate roles in regulating the biology of embryonic stem cells and tumor suppression, and they help define the selection of cell fate and the progression of differentiation along a linea...
متن کاملTransforming growth factor-beta signaling and ubiquitinators in cancer.
Transforming growth factor-beta (TGF-beta) represents a large family of growth and differentiation factors that mobilize complex signaling networks to regulate cellular differentiation, proliferation, motility, adhesion, and apoptosis. TGF-beta signaling is tightly regulated by multiple complex mechanisms, and its deregulation plays a key role in the progression of many forms of cancer. Upon li...
متن کاملTransforming growth factor-beta signaling in breast cancer.
Transforming growth factor-beta (TGF-beta) is a multifunctional polypeptide that regulates cell growth, differentiation, and extracellular matrix formation. Studies on genetically engineered animal models have demonstrated that TGF-beta-mediated signaling pathway plays a critical role in both normal development and tumorigenesis of the breast. In pathogenesis of breast cancer, the role of TGF-b...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Developmental Biology
سال: 2011
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2011.05.297